The upper limit of normal for thyrotropin is 3 or 4 milli-int. units/L.
نویسنده
چکیده
Recently Musto et al. (Clin Chem 30: 329-330, 1984) noted that, despite the clinical importance of accurate measurement of thyrotropin at low concentrations, the upper limit of normal is well below the stated upper limit of normal of most commercial tests. Here I amplify their statement.
منابع مشابه
Determination of thyrotropin in serum by time-resolved fluoroimmunoassay evaluated.
We evaluated a new, highly sensitive time-resolved fluoroimmunoassay for thyrotropin (TSH) in serum. This direct immunometric "sandwich"-type assay involves two monoclonal antibodies against TSH, one immobilized, the other labeled with europium. Extremely high specific activity of the label and the use of labeled antibody in large excess make the method sensitive enough to measure TSH values fa...
متن کاملChemiluminescence immunoassay of thyrotropin with acridinium-ester-labeled antibody evaluated and compared with two other immunoassays.
A new chemiluminometric immunoassay of thyrotropin (TSH) involves antibody labeled with acridinium ester ("Magic Lite System," Ciba Corning Diagnostic Corp.). The assay is rapid, with two incubations totaling 2.5 h, requires two standards per run, and takes 10 s per sample for the quantification step. Analytical performance, within- and between-run reproducibilities, and linearity were excellen...
متن کاملUitrasensltlve Bioassay of Thyrotropin,
Radioimmunoassay of thyrotropin (TSH) is well-established, and highly sensitive radioimmunometric assay is often used clinically (1). Some recent results indicate that TSH immunoreactivity and bioactivity are not always synonymous (2). The detection limit of present bioassays for bovine TSH is about 0.5-1 milli-int. unit/L (3-6). More-sensitive bioassay is necessary for evaluating human TSH. Th...
متن کاملHigh sensitivity, homogeneous particle-based immunoassay for thyrotropin (Multipact).
We describe the first homogeneous, nonradioactive, high-sensitivity assay for human thyrotropin (TSH). The assay is based on particle immunoassay techniques, wherein 800-nm particles form the basis for the immunochemistry, delivery, and the detection technologies, respectively. Our assay also is the first to involve the use of fragmented monoclonal antibodies (to eliminate serum interferences) ...
متن کاملSpecificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients.
Thyrotropin (TSH) concentrations were measured in 1580 hospitalized patients and 109 normal persons. Using the mean +/- 3 SD limits of the log values for the controls (0.35-6.7 milli-int. units/L), the proportion of abnormal TSH results in the hospitalized patients was 17.2%. TSH was undetectable (less than 0.1 milli-int. unit/L) in 3.1% of patients, suggesting hyperthyroidism, and high (greate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Clinical chemistry
دوره 31 2 شماره
صفحات -
تاریخ انتشار 1985